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3 Jun 2013 Moreover, the method was used to search for endogenous targets in the MYCN-amplified neuroblastoma cell line SK-N-BE(2)c. The pull-down results of mir-34a yielded high enrichment of MYCN and CCND1 (cyclin D1). Additionally, SIRT1 was a probable target of mir-34a. Two mRNAs that previously